Table 1 Animal models of arthritis
From: Characterization of a novel and spontaneous mouse model of inflammatory arthritis
Model | Abbreviation | Species | Feature |
|---|---|---|---|
Induced models | Â | Â | Â |
   Non-specific immune stimuli |  |  |  |
Adjuvant-induced arthritis | AA | Lewis rat | Autoimmune |
Oil-induced arthritis | OIA | DA rat | Autoimmune |
Pristane-induced arthritis | PIA | DA ra | Autoimmune |
   Cartilage directed autoimmunity |  |  |  |
Collagen-induced arthritis | CIA | DBA mouse | CII AI |
Proteoglycan-induced arthritis | PGIA | Balb/c mouse | PG AI |
   Infectious agents/exogenous triggers |  |  |  |
Streptococcal cell wall arthritis | SCW-A | Lewis rat | Persistent bacteria AI |
Flare | SCW-F | Mouse | Th17 |
Antigen-induced arthritis | AIA | Rabbit, mouse | Persistent antigen |
Flare | AIA-F | Mouse | Th17 |
Transgenic spontaneous models | Â | Â | Â |
   HTLV-induced arthritis | HTLV | Mouse | Viral tax antigen |
   KRN arthritis | KRN | K/BxN mouse | GPI AI |
   SKG arthritis | SKG | Mouse | ZAP-70 T cell defect |
   GP130 arthritis | GP130 | Mouse | STAT3, T cell defect |
   TNF transgenic arthritis | TNFtg | Mouse | TNF overexpression |
   IL-1ra transgenic arthritis | IL-1ra-/- | Balb/c mouse | Autoimmune T cells |
   IL-1 transgenic arthritis | IL-1tg | Mouse | IL-1 overexpression |
Immune complex models | Â | Â | Â |
   Collagen type II | CAIA | DBA mouse | Mouse CII antibody |
   KRN serum | GPI | Balb/c mouse | Mouse GPI antibody |
   Poly-L-lysine-lysozyme | PLL-L | DBA mouse | Cationic antigen |
New animal model | Â | Â | Â |
   Spontaneous |  |  |  |
Inherited inflamed joints strain | IIJ | Arthritic male mouse crossed with SJL/J females | Autoimmune arthritis (for understanding the female bias) |