Figure 3From: Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokinesEffect of DEX on human knee cartilage treated with TNFα and TNFα in combination with injury and IL-6/sIL-6R. The percentage of GAG loss was measured from 10-day treatments. All cartilage disks included superficial surface. The total GAG content was 168.9 ± 17.1 μg GAG/disk in the untreated control group. 100 nM DEX significantly reduced GAG release induced by treatments with TNFα, IL-6/sIL-6R and mechanical injury. In each condition, n = 6 cartilage disks. * = P < 0.05 (only comparisons from selected hypothesis are shown). DEX, dexamethasone; GAG, glycosaminoglycans; IL-6, interleukin-6; sIL-6R, soluble interleukin-6 receptor; TNFα, tumor necrosis factor alpha.Back to article page