The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge

Table 3 The comparative gene expression profiles of preclinical arthritis rats and Bhsp65-tolerized rats for the subsets of genes that play a role in the pathogenesis of arthritis^a

		Fold change (compared to baseline)
Gene symbol	Gene name	Preclinical arthritis rats	Bhsp65-tolerized rats
Costimulatory molecule
Cd86	CD86 molecule	#	+2.06*
Cytokine or cytokine receptor
Ifi47	Interferon γ-inducible protein 47	+2.44*	+2.37*
Ifi27l1	Interferon α-inducible protein 27-like 1	+2.14*	#
Il1a	Interleukin 1α	+4.61*	+3.21*
Il1b	Interleukin 1β	#	+3.05*
Lta	Lymphotoxin α (TNF superfamily, member 1)	#	+2.10*
Socs1	Suppressor of cytokine signaling 1	+3.67*	+3.14*
Socs3	Suppressor of cytokine signaling 3	#	+2.44*
Ifng	Interferon γ	+10.00*	+9.09*
Il12rb2	Interleukin 12 receptor β2	+4.08*	+3.89*
Il10	Interleukin 10	#	+2.07*
Il33	Interleukin 33	-2.50*	#
LOC301289	Similar to interleukin 17 precursor (IL-17)	+16.74*	#
Il17f	Interleukin 17F	+7.86*	#
RGD1561292	Interleukin 22	+7.26*	#
Chemokine/receptor
Cxcl10	Chemokine (C-X-C motif) ligand 10	+8.02*	+8.15*
Ccr5	Chemokine (C-C motif) receptor 5	+2.22*	+2.50*
Cxcr7	Chemokine (C-X-C motif) receptor 7	-2.47*	#
Angiogenesis
Wars	Tryptophanyl RNA synthetase	+2.29*	+2.17*
Vegfa	Vascular endothelial growth factor A	#	+2.21*
Nos2	Nitric oxide synthase 2, inducible	+7.83*	+4.77*
Others
Bst2	Bone marrow stromal cell antigen 2	+2.90*	+3.04*
Slc7a2	Solute carrier family 7 (cationic amino acid transport)	+4.98*	+4.15*

^aBhsp65: mycobacterial heat shock protein 65. The genes listed were selected using false discovery rate < 5% and ≥2-fold change as the cutoff; +, upregulation; -, downregulation (- number); *significant compared to the corresponding baseline expression; #not significant compared to the corresponding baseline expression.

ISSN: 1478-6362