Table 2 Effect of CNP on gene expression in chondrocyte/agarose constructs

Culture period (hr)

6

48

6

48

6

48

6

48

6

48

6

48

6

48

6

48

Collagen type I

^a

^a

ND

ND

↑^b

↑^c

ND

ND

ND

ND

^a

↓^d

ND

ND

ND

ND

Collagen type II

↑^b

^a

↓^d

↓^d

^a

^a

^a

^a

^a

^a

^a

↑^c

↓^d

↓^d

^a

^a

Col X

^a

^a

^a

^a

↑^b

↑^c

↑ ^b

↑ ^c

↓ ^d

↓^d

^a

^a

^a

^a

^a

^a

Sox-9

^a

^a

ND

ND

^a

^a

ND

ND

ND

ND

↑^b

↑^c

ND

ND

ND

ND

MMP-13

^a

^a

↑^b

↑^c

↑^b

↑^b

↑^b

↑^c

↓^d

↓^d

^a

^a

↓^d

↓^d

^a

^a