| ACA (310) | ATA (260) | Anti-PM-Scl (42) | Anti-U1-RNP (41) | Anti-RNA -P (33) | Anti-Fibrillarin (12) | Anti-Ku (10) | Anti-Ro52 (187) | Anti-Ro60 (59) | Anti-La (16) | AMA (41) | Anti-p25/23 (28) | ANA-negative (50) | no SSc associated ab's (161) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
male sex 148 (17.1%) | 17 0.19 (0.11 to 0.32) P < 0.0001 | 64 2.02 (1.4 to 2.91) p = 0.0002 | 6 | 9 | 8 | 4 | 2 | 23 0.62 (0.38 to 0.997 p = 0.049 | 12 | 2 | 1 | 1 | 10 | 41 1.90 (1.261 to 2.863) p = 0,0035 |
age at disease onset < 50 y 399/781 (51.1%) | 115 0.57 (0.43 to 0.77) p = 0.0003 | 135 1.39 (1.02 to 1.88) p = 0.0431 | 22 | 29 2.92 (1.40 to 6.07) p = 0.0029 | 13 | 8 | 4 | 77 | 31 | 10 | 20 | 8 | 18 | 73 |
Rodnan skin score > 10 294/750 (39.2%) | 58 0.27 (0.19 to 0.38) P < 0.0001 | 132 3.10 (2.24 to 4.27) P < 0.0001 | 14 | 9 | 18 3.24 (1.44 to 7.31) p = 0.0042 | 7 | 1 | 58 | 23 | 6 | 10 | 11 | 14 | 56 |
Raynaud's phenomenon 819 (94.9%) | 301 2.26 (1.07 to 4.77) p = 0.0349 | 252 | 37 | 41 | 32 | 12 | 10 | 184 3.96 (1.2 to 12.94 p = 0.0133 | 58 | 16 | 41 | 28 | 43 0.29 (0.12 to 0.70) p = 0.0104 | 140 0.23 (0.12 to 0.42) P < 0.0001 |
Digital ulcers 216/840 (25.7%) | 55 0.50 (0.36 to 0.71) P < 0.0001 | 106 3.18 (2.30 to 4.41) P < 0.0001 | 9 | 11 | 7 | 4 | 1 | 48 | 19 | 6 | 13 | 6 | 4 0.26 (0.09 to 0.76) p = 0.0076 | 28 0.60 (0.39 to 0.94) p = 0.024 |
Pulmonary hypertension 126 (14.6%) | 57 1.58 (1.08 to 2.32) p = 0.0208 | 36 | 2 | 9 | 4 | 1 | 0 | 31 | 14 | 2 | 2 | 7 | 2 0.23 (0.06 to 0.97) p = 0.0232 | 17 |
Pulmonary fibrosis 287 (33.3%) | 39 0.18 (0.12 to 0.26) P < 0.0001 | 151 4.76 (3.48 to 6.50) P < 0.0001 | 16 | 11 | 7 | 2 | 6 | 69 | 30 2.20 (1.29 to 3.75 p = 0.0040 | 9 | 6 0.33 (0.14 to 0.79) p = 0.01 | 4 0.33 (0.11 to 0.95) p = 0.0393 | 11 | 55 |
Lung restrictive defect 218/833 (26.2%) | 41 0.31 (0.21 to 0.45) P < 0.0001 | 104 2.96 (2.14 to 4.09) P < 0.0001 | 9 | 7 | 8 | 3 | 4 | 45 | 19 | 4 | 8 | 4 | 10 | 34 |
Esophageal involvement 535 (62.0%) | 198 | 175 1.39 (1.02 to 1.89) p = 0.039 | 14 0.29 (0.152 to 0.56) p = 0.0001 | 29 | 20 | 7 | 6 | 120 | 39 | 13 | 24 | 21 | 27 | 87 0.67 (0.47 to 0.94) p = 0.0243 |
Proteinuria 90/830 (10.8%) | 23 0.56 (0.34 to 0.92) p = 0.0207 | 34 | 4 | 4 | 4 | 1 | 1 | 15 | 9 | 2 | 3 | 1 | 5 | 19 |
Cardiac involvement 114 (13.2%) | 27 0.51 (0.32 to 0.81) p = 0.0033 | 45 1.62 (1.08 to 2.44) p = 0.0216 | 5 | 7 | 5 | 1 | 2 | 20 | 9 | 1 | 4 | 1 | 5 | 22 |
Musculoskeletal involvement 421/852 (49.4%) | 131 0.64 (0.48 to 0.85) p = 0.0022 | 130 | 20 | 28 2.49 (1.25 to 4.96) p = 0.009 | 17 | 10 5.22 (1.14 to 23.97) p = 0.0202 | 6 | 80 0.71 (0.51 to 0.99) p = 0.0468 | 32 | 12 3.13 (1.002 to 9.79) p = 0.0447 | 17 | 9 | 25 | 79 |
Synovitis 157/837 (18.8%) | 35 0.43 (0.29 to 0.65) P < 0.0001 | 62 1.71 (1.19 to 2.45) p = 0.0049 | 8 | 13 2.27 (1.14 to 4.53) p = 0.0326 | 8 | 2 | 2 | 32 | 15 | 5 | 2 0.21 (0.05 to 0.89) p = 0.0216 | 2 | 10 | 29 |
Joint contractures 253/840 (30.1%) | 54 0.36 (0.25 to 0.50) P < 0.0001 | 107 2.26 (1.65 to 3.08) P < 0.0001 | 9 | 9 | 10 | 6 | 2 | 49 | 23 | 6 | 9 | 9 | 20 1.93 (1.05 to 3.54) p = 0.0436 | 56 |
Tendon friction rubs 88/840 (10.5%) | 14 0.30 (0.16 to 0.53) P < 0.0001 | 32 | 2 | 5 | 6 | 3 | 1 | 21 | 5 | 2 | 2 | 0 | 6 | 25 1.95 (1.18 to 3.22) p = 0.0122 |
CK elevation 74/835 (8.9%) | 14 0.37 (0.21 to 0.68) p = 0.0009 | 20 | 19 3.56 (1.67 to 7.57) p = 0.0023 | 5 | 6 2.60 (1.03 to 6.55) p = 0.0485 | 0 | 3 5.32 (1.30 to 21.72) p = 0.038 | 21 | 8 | 2 | 1 | 0 | 6 | 16 |
Sicca syndrome 366/858 (42.7%) | 150 1.44 (1.19 to 6.61) p = 0.0119 | 98 | 14 | 18 | 12 | 5 | 4 | 96 1.57 (1.13 to 2.17) p = 0.0075 | 33 1.85 (1.08 to 3.17) p = 0.0275 | 12 4.14 (1.32 to 12.93) p = 0.0102 | 19 | 20 3.50 (1.52 to 8.03) p = 0.0029 | 23 | 66 |
Mouth involvement 223/829 (26.9%) | 64 0.61 (0.44 to 0.85) p = 0.0034 | 93 2.1 (1.53 to 2.93) P < 0.0001 | 10 | 7 | 10 | 3 | 4 | 49 | 18 | 6 | 11 | 6 | 12 | 34 |
ESR > 25 mm/h 199/741 (26.9%) | 58 0.70 (0.49 to 0.99) p = 0.046 | 75 1.55 (1.10 to 2.19) p = 0.015 | 4 0.33 (0.11 to 0.94) p = 0.0325 | 14 | 5 | 0 | 0 | 60 1.76 (1.21 to 2.54) p = 0.0039 | 28 3.39 (1.92 to 5.97) P < 0.0001 | 9 3.62 (1.33 to 9.86) p = 0.0447 | 10 | 5 | 15 | 42 |