Quantitative traits | Clinical data | ||
---|---|---|---|
Age at disease onset | n | Mean ± SD (years) | P* |
   Total | 781 | 47.7 (14.2) |  |
   Anti-centromere | 273 | 51.3 (12.5) | < 0.0001 |
   Anti-topoisomerase I | 238 | 46.0 (14.0) | 0.0076 |
   Anti-fibrillarin | 12 | 38.8 (16.0) | 0.0404 |
   Anti-U1-RNP | 39 | 38.2 (15.0) | < 0.0001 |
   Anti-La | 15 | 37.9 (18.1) | 0.0431 |
   Autoantibody-negative | 36 | 52.9 (14.7) | 0.0205 |
Rodnan skin score | n | Mean score ± SD | P |
   Total | 750 | 10.2 (9.4) |  |
   Anti-centromere | 275 | 6.4 (6.0) | < 0.0001 |
   Anti-topoisomerase I | 227 | 14.1 (9.7) | < 0.0001 |
   Anti-RNA polymerase | 27 | 15.7 (11.7) | 0.0091 |
   Anti-fibrillarin | 10 | 21.2 (15.0) | 0.0108 |
   Anti-U1-RNP | 35 | 6.9 (9.2) | 0.0053 |
Erythrocyte sedimentation rate | n | Mean ± SD (mm/hour) | P |
   Total | 741 | 19.46 (16.7) |  |
   Anti-topoisomerase I | 227 | 22.95 (19.1) | 0.0002 |
   Anti-PM-Scl | 36 | 12.19 (9.4) | 0.0014 |
   Anti-Ro52 | 167 | 22.05 (18.8) | 0.0374 |
   Anti-Ro60 | 53 | 28.47 (19.6) | < 0.0001 |
   Anti-La | 16 | 28.56 (20.1) | 0.0447 |