Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes

Table 3 Differential protein spots from pSS, healthy volunteers and non-SS sicca syndrome patients (P <0

Spot No	Accession No	Protein name	Gene name	Mean ± SD (pSS)	Mean ± SD (healthy)	Mean ± SD (sicca non-SS)	Fold of variation pSS vshealthy	Fold of variation pSS vssicca non-SS
2261	P04745	α-amylases precursor	AMY1A	2.58 ± 0.44	4.77 ± 0.39	4.24 ± 0.67	-1.8**	-1.6**
2572	Q5FC00	Carbonic anhydrase VI	CA6	0.65 ± 0.11	1.50 ± 0.47	1.07 ± 0.26	-2.3*	-1.6*
2642	P04406	G3PDH	GAPDH	0.07 ± 0.03	0.31 ± 0.03	0.23 ± 0.85	-4.4***	-3.2*
2543	P06733	α-enolase	ENO1	0.08 ± 0.02	0.04 ± 0.01	0.05 ± 0.03	+2**	+1.6
2842	Q6GMW1	IGKC	IGKC	1.33 ± 0.49	0.17 ± 0.30	0.54 ± 0.42	+7.8*	+2.5
3018	P31151	Protein S100-A7 (Psoriasin)	S100A7	0.47 ± 0.21	0.09 ± 0.04	0.32 ± 0.15	+5.2*	+1.5
3000	P06702	Protein S100-A9 (Calgranulin B)	S100A9	2.98 ± 0.10	2.00 ± 0.42	2.75 ± 0.54	+1.5*	ns
2986	P01037	Cystatin SN precursor	CST1	0.91 ± 0.36	2.37 ± 0.01	0.84 ± 0.44	-2.6**	ns
2938	P12273	PIP	PIP	0.05 ± 0.08	0.33 ± 0.01	0.09 ± 0.17	-6.6**	-1.8
2655	Q96DR5	SPLUNC-2	SPLUNC2	0.04 ± 0.07	0.40 ± 0.17	0.40 ± 0.18	-10*	-10*
3003	Q01469	E-FABP	FABP5	0.17 ± 0.07	0.02 ± 0.03	0.06 ± 0.05	+8.5*	+2.8*
3036	P61769	β-2 microglobulin	B2M	0.39 ± 0.04	0.17 ± 0.04	0.23 ± 0.05	+2.3**	+1.7

NB, values that are significantly different from pSS (*P <0.05, **P <0.01, ***P <0.001) as determined by statistical analysis. E-FABP, epidermal fatty acid binding protein; G3PDH, glyceraldehydes-3-phosphate dehydrogenase; IGKC, immunoglobulin k light chain; PIP, prolactin-inducible protein precursor; pSS, primary Sjögren's syndrome; SPLUNC-2, lung and nasal epithelium clone 2; SS, Sjögren's syndrome

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