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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis

Figure 5

Coronal micro-CT image (A) and histology section (B) of tibia from an MIA-injected knee, showing subchondral plate breach by the activated chondrocytes as a result of abnormal repair, as indicated by arrows (A, B). Micro-CT image revealed the presence of focal subchondral bone lesions in the medial tibial plateau (C) at ten weeks post injection (rectangle). The safranin O and fast green stained section of the MIA-injected knee at ten weeks post injection (D) confirmed the presence of subchondral bone cyst in the areas of bone lesions as predicted by micro-CT image. The cysts were found to be surrounded by sclerotic bone with fibrous tissue containing debris of necrotic bone. Note the presence of large active osteoblasts (arrow) lining the trabeculae adjacent to the sites of bone resorption. Original magnification × 100. Micro-CT, micro-computed tomography; MIA, monosodium iodoacetate.

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Arthritis Research & Therapy

ISSN: 1478-6362

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