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Figure 9 | Arthritis Research & Therapy

Figure 9

From: Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis

Figure 9

Coronal sections stained with Safranin O and fast green of a control tibia (A) and of a MIA-injected tibia (B-D) showing the cartilage on the medial tibial plateau, at ten weeks post injection. The control tibia (A) showed normal healthy cartilage with normally distributed chondrocytes. The MIA-injected tibia (B) showed loss of proteoglycans, loss of viable chondrocytes, chondrocyte proliferation (arrow), and chondrocyte cluster formation of variable sizes (arrowhead). The cartilage showed fibrillation, vertical fissures (C, arrow) and delamination (D). The subchondral trabecular bone architecture was altered with sclerosed bone (C) and the cellular bone marrow was replaced by loosely arranged spindle cells in a fine fibrous stroma (D, arrow). Original magnification ×100. MIA, monosodium iodoacetate.

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Arthritis Research & Therapy

ISSN: 1478-6362

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