Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort

Table 3 Independent correlates of antibodies to RNA polymerase III determined using logistic regression

Variable ^a	Odds ratio	95% confidence interval	P value
Renal crisis^b	3.8	1.2 to 11.5	0.02
Diffuse subtype^c	6.4	2.9 to 13.8	< 0.0001
Joint contractures	2.5	1.2 to 5.3	0.02
Anti-topoisomerase antibodies	0.01	0.002 to 0.11	< 0.0001
Anti-centromere antibodies	0.13	0.04 to 0.41	0.0005

In this model, after adjustment for other significant covariates, myositis and synovitis were no longer statistically significant and were therefore removed from model. Univariate odds ratio of RNA polymerase III for renal crisis is 17.4 (95% confidence interval 6.9 to 43.9, P < 0.0001). ^aEver from disease onset (defined as date of onset of first systemic-sclerosis-related manifestation other than Raynaud's phenomenon) to most recent visit. ^bRenal crisis defined as abrupt onset severe hypertension (systolic blood pressure ≥ 180 mmHg and/or diastolic blood pressure ≥ 100 mmHg) without an alternate etiology, with or without microangiopathic anemia or decline in renal function. ^cDisease subtype classified based on extent of skin involvement, with limited disease being confined to extremities and face.

ISSN: 1478-6362