| Female swima | Female sedentaryb | Male swima | Male sedentaryb |
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 | Controlc | 0.1 DESc | 1.0 DES | 10.0 DES | Control | 0.1 DES | 1.0 DES | 10.0 DES | Control | 0.1 DES | 1.0 DES | 10.0 DES | Control | 0.1 DES | 1.0 DES | 10.0 DES |
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No. of pups | 8 | 6 | 8 | 8 | 9 | 7 | 5 | 11 | 6 | 8 | 5 | 7 | 11 | 8 | 7 | 9 |
- aFemale or male mice were put on a once-daily swimming regimen, which started as 5 minutes and was escalated to a maximum of 1 hour within 1 week. bFemale or male mice were left to their normal activity level and considered sedentary. cPregnant C57/bl mice were injected with either vehicle (peanut oil) or one of three doses of DES (0.1, 1.0, and 10.0 μg/kg/day) at 11 to 14 days of gestation.