Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study

Table 2 Summary of the presence, extent, and localization of citrullination and PAD isotypes in the myocardium of RA patients

	Cardiomycocytes	VSMCs	Endothelium	Leukocytes	Extracellular matrix
Citrullination	Absent	Absent	Absent	Absent	+++
PAD1	+++^a	Absent	Absent	+	Absent
PAD2	+^b	+	+	+++	Absent
PAD3	+++^{a, c}	++	+	++	Absent
PAD4	+^b	+	+	+++	Absent
PAD6	+^b	++	++	Absent	Absent

^aGranular staining pattern; ^bcytoplasmic staining pattern; ^cnuclear staining pattern.
PAD, peptidyl-arginine deiminase; VSMC, vascular smooth muscle cells.

ISSN: 1478-6362