Figure 1

Stimulation index of dose-dependent induction of IL-8, IL-6, matrix metalloproteinase-1 (MMP-1) and prostaglandin E₂ (PGE₂) by hTWEAK in 10 experiments on dermal fibroblasts and four experiments on synoviocytes. Polymyxin B-treated cells (2 × 10⁴/well) were incubated for 72 hours in the presence of human TNF-like weak inducer of apoptosis (hTWEAK) at the indicated doses. Supernatants from dermal fibroblasts or synoviocytes were tested by ELISA for the different products. Values are shown as mean ± SEM. Except for PGE₂, Mann–Whitney P values at 50 ng/ml and at 100 ng/ml versus control were significant (P < 0.02).