From: Exercise training in pulmonary arterial hypertension associated with connective tissue diseases
Characteristic | Baseline (n= 21) | 3 weeks (n= 21) | P-value | 15 weeks (n= 14) | P-value | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
6-minute walking distance, m | |||||||||||
Mean change | 386 | ± | 121 | 425 | ± | 118 | 447 | ± | 139 | ||
64 | ± | 17 | < 0.001a | 71 | ± | 35 | 0.003 | ||||
95% CI for the difference to baseline | 42 | - | 85 | 48 | - | 95 | |||||
Quality of life questionnaire SF36, score | |||||||||||
Physical functioning | 33.5 | ± | 20 | 0.025b | 45.2 | ± | 20 | 0.025b | |||
Role-physical | 60.4 | ± | 36 | 0.317 | 65.6 | ± | 23 | 0.317 | |||
Bodily pain | 58.1 | ± | 33 | 0.260 | 62.2 | ± | 31 | 0.260 | |||
General health perception | 31.6 | ± | 15 | 0.049b | 35.9 | ± | 14 | 0.049b | |||
Vitality | 38.1 | ± | 14 | 0.021b | 48.1 | ± | 18 | 0.021b | |||
Social functioning | 61.8 | ± | 30 | 0.008a | 71.4 | ± | 23 | 0.008a | |||
Role-emotional | 77.6 | ± | 22 | 0.115 | 91.6 | ± | 14 | 0.115 | |||
Mental Health | 56.8 | ± | 21 | 0.033b | 66.2 | ± | 16 | 0.033b | |||
Cardiopulmonary exercise testing | |||||||||||
Peak VO2/kg, mL/min/kg | 11.8 | ± | 3.4 | 13.6 | ± | 3.4 | 0.010b | 14.1 | ± | 3.5 | 0.008a |
Peak VO2, ml/min | 822 | ± | 252 | 882 | ± | 218 | 0.011b | 887 | ± | 139 | 0.007a |
EqCO2 at AT, ml/min | 41.3 | ± | 8.9 | 41.3 | ± | 9.5 | 0.529 | 42.8 | ± | 7.1 | 0.138 |
VO2 at AT; ml/min | 619 | ± | 172 | 689 | ± | 207 | 0.013b | 681 | ± | 207 | 0.012b |
Oxygen pulse, (mL/min)/min-1 | 6.7 | ± | 1.6 | 6.8 | ± | 1.8 | 0.127 | 6.3 | ± | 0.4 | 0.260 |
HR rest, min-1 | 85 | ± | 14 | 77 | ± | 12 | 0.0001a | 78 | ± | 16 | 0.045b |
HR max, min-1 | 122 | ± | 21 | 127 | ± | 18 | 0.076 | 140 | ± | 20 | 0.005a |
RRsys rest, mmHg | 117 | ± | 17 | 114 | ± | 15 | 0.092 | 111 | ± | 15 | 0.653 |
RRdiast rest, mmHg | 75 | ± | 8 | 71 | ± | 9 | 0.038b | 72 | ± | 8 | 0.464 |
RRsys max, mmHg | 149 | ± | 28 | 154 | ± | 18 | 0.743 | 153 | ± | 18 | 0.002a |
RRdias max, mmHg | 85 | ± | 13 | 88 | ± | 14 | 0.292 | 88 | ± | 12 | 0.083 |
Oxygen saturation rest, % | 94.7 | ± | 3.0 | 96.7 | ± | 3.2 | 0.266 | 96.4 | ± | 2.8 | 0.421 |
Oxygen saturation max, % | 89.8 | ± | 5.6 | 90.8 | ± | 5.8 | 0.052 | 91.7 | ± | 6.3 | 0.018b |
sPAP rest, mmHg | 52 | ± | 14 | 47 | ± | 9 | 0.005a | 50 | ± | 10 | 0.210 |
sPAP max, mmHg | 85 | ± | 26 | 87 | ± | 20 | 0.959 | 89 | ± | 14 | 0.320 |
Workload max, W | 55 | ± | 19 | 67 | ± | 23 | 0.007a | 65 | ± | 20 | 0.008a |
Borg Scale, score | 16 | ± | 2 | 15 | ± | 2 | 0.171 | 15 | ± | 1 | 0.105 |
Laboratory parameters | |||||||||||
C-reactive protein, mg/l | 15.2 | ± | 22.5 | 8.3 | ± | 9.7 | 0.069 | 6.6 | ± | 5.3 | 0.071 |
Leucocytes, 109/l | 9.2 | ± | 7.5 | 10.0 | ± | 12.9 | 0.071 | 8.6 | ± | 7.6 | 0.177 |
NT-proBNP, pg/ml | 1928 | ± | 4623 | 1101 | ± | 1380 | 0.164 | 2321 | ± | 2671 | 0.646 |