From: Gene therapy using IL-27 ameliorates Sjögren's syndrome-like autoimmune exocrinopathy
Disease stage | Salivary glands | Lacrimal glands | |||
---|---|---|---|---|---|
Treatment | LF | Meana | LF | Mean | |
Saline | 5/6b (83%)c | 2.3 ± 1.5 | 4/6 (67%) | 2.8 ± 1.3 | |
Pre-disease | Lac-Z | 7/7 (100%) | 3.0 ± 2.4 | 6/7 (86%) | 1.5 ± 0.7 |
IL-27 | 6/7 (86%) | 4.3 ± 2.2 | 2/7d (29%) | 2.0 ± 1.4 | |
Clinical disease | Lac-Z | 7/7 (100%) | 3.4 ± 2.4 | 4/7 (57%) | 2.5 ± 1.0 |
IL-27 | 7/7 (100%) | 3.4 ± 1.3 | 2/7 (29%) | 4.5 ± 5.0 |