System | Type of diagnostic procedure | Intervals |
---|---|---|
Hematopoietic system | Blood formula and differential blood counts | (3-)6 months; more often in case of known autoimmune cytopenia |
 | Coombs test in any case of newly developing anemia | On demand |
 | Bone marrow biopsy in case of suspicion of lymphoma or myelodysplasia | On demand at diagnosis or during follow-up |
Immune system | IgG, IgA, IgM (aiming at trough levels >7g/L) | Â |
 | In intravenous immunoglobulin-substituted patients | Monthly trough levels |
 | In subcutaneous immunoglobulin-substituted patients | 1-3 months |
 | Immunofixation in serum and urine, ß2-microglobulin | At diagnosis |
 | CD3, CD4, CD8, CD19, CD56 lymphocyte subsets | Initially and repeatedly in case of suspected combined immunodeficiency |
 | Vaccination responses to tetanus, diphtheria, hepatitis, pneumococcal polysaccharides | At diagnosis |
 | Classification (detailed T/B-cell evaluation) | At diagnosis |
Microbiology (direct culture of pathogens, PCR, antigen ELISA) | Purulent sputum: determine colonizing pathogens and resistance pattern to antibiotics | On demand |
 | In case of chronic bronchiectasis, control of colonising pathogens (Pseudomonas spp., Haemophilius influenzae, Streptococcus pneumoniae, Staphylococcus aureus, Candida spp. and others) with sensitivity to antibiotics | 6-12 months and on demand |
Lungs | Spirometry, CO diffusion test, blood gases | 12 months |
 | Chest X-ray | (12-)24 months |
 | HR-CT in case of proven GILD | 24 months and on demand |
 | Bronchoscopy + BAL in case of suspicion of GILD | At diagnosis; on demand |
Lymphoproliferation | Abdomen sonography CT-Abdomen/MRT | 12 months |
 | Lymph node biopsy | On demand; in case of suspected lymphoma |
Gastrointestinal tract | Oesophogastroscopy | In case of clinical symptoms and every |
 |  | 24 months in case of increased risk for developing intestinal malignancy |
 | Colonoscopy | On demand |
Central nervous system | MRT, liquor analysis in case of neurological symptoms (exclusion of enteroviral infection) | On demand |