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Figure 9 | Arthritis Research & Therapy

Figure 9

From: The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

Figure 9

Adiponectin suppresses fibrotic responses. Ligands of PPAR-γ induce adiponectin which triggers autocrine or paracrine activation of AMP kinase. AMP kinase in turn blocks TGF-β/Smad signaling and consequent stimulation of profibrotic gene expression. PPAR-γ, peroxisome proliferator activated receptor gamma; TGF-β, transforming growth factor-β.

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Arthritis Research & Therapy

ISSN: 1478-6362

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