Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors

Table 1 Gene ontology (GO) analysis of genes differentially expressed in control and proteoglycan-induced spondylitis (PGISp) mouse spines

GO category	GO term	Number of genes	LS permutation P-value	KS permutation P-value	Efron-Tibshirani's GSA test P-value
GO:0002252	immune effector process	225	0.00001	0.00196	< 0.005 (+)
GO:0002376	immune system process	995	0.00001	0.00002	0.005 (+)
GO:0002444	myeloid leukocyte mediated immunity	18	0.00001	0.00179	0.005 (+)
GO:0002682	regulation of immune system process	374	0.00001	0.01936	0.005 (+)
GO:0002684	positive regulation of immune system process	255	0.00001	0.00417	0.005 (+)
GO:0006954	inflammatory response	293	0.00001	0.00007	< 0.005 (+)
GO:0006955	immune response	562	0.00001	0.00001	0.005 (+)
GO:0032963	collagen metabolic process	30	0.00007	0.01778	0.005 (+)
	Osteoblast genes	16	0.00105	0.00005	0.02 (+)

Gene expression levels in a number of inflammatory pathways, as well as an osteoblast gene set are altered in PGISp spine samples. LS, log summary; KS, Kolmogorov-Smirnov summary; GSA, gene set analysis.

ISSN: 1478-6362