Follow-up | DAS28 | Medication |
---|---|---|
Week 0 | ≥ 2.6 | Methotrexate 15 mg/wk |
Week 8 | ≥ 2.6 | Methotrexate 25 mg/wk |
Week 12 | ≥ 2.6 | Methotrexate 25 mg/wk + sulfasalazine 2,000 mg/day |
Week 20 | ≥ 2.6 | Methotrexate 25 mg/wk + sulfasalazine 3,000 mg/day |
Week 24 | ≥ 3.2†| Methotrexate 25 mg/wk + adalimumab 40 mg every 2 weeks |
Week 36 | ≥ 2.6 and decrease of > 1.2‡ | Methotrexate 25 mg/wk + adalimumab 40 mg/week |
Week 52 | ≥ 3.2†| Methotrexate 25 mg/wk + etanercept 50 mg/week |
1 year + 3 months | ≥ 3.2†| Methotrexate 25 mg/wk + infliximab 3 mg/kg every 8 weeks (after a loading dose at weeks 0, 2 and 6) |
1 year + 6 months | ≥ 2.6 and decrease of > 1.2‡ | Methotrexate 25 mg/wk + infliximab 3 mg/kg every 4 weeks |