Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus

Table 3 Univariate and multivariate logistic regression analysis of potential risk factors during 12-month follow up in pediatric-onset systemic lupus erythematosus (pSLE)*

			Univariate analysis		Multivariate analysis
Variable	AMS < 3.7	AMS > 3.7	OR (95% CI)	P-value	OR (95% CI)	P-value
Osteopontin high	8	3	2.1 (0.39, 10.8)	0.4
NGAL high	7	2	0.8 (0.14, 4.8)	0.9
Cumulative prednisone exposure	12	3	0.7 (0.15, 3.2)	0.7
Disease duration > 2 years	16	4	0.6 (0.15, 3.2)	0.7
Renal involvement	22	7	1.4 (0.3, 8.3)	0.9
Non-Caucasian background	25	10	5.4 (0.28, 104)	0.3
Male gender	8	2	0.8 (0.04, 3.1)	0.9
	ΔSDI = 0	ΔSDI > 0
Osteopontin high	6	4	9 (1.5, 60)	0.015	7.5 (2.9, 20)	0.03
NGAL low	8	2	1.3 (0.21, 8)	0.9	1.16 (0.14, 9.3)	0.9
Cumulative prednisone exposure	11	4	2.8 (0.5, 14.7)	0.4
Disease duration > 2 years	17	2	0.4 (0.08, 2.4)	0.4
Renal involvement	24	5	2.1 (0.2, 20.2)	0.9
Non-Caucasian background	28	7	3.4 (0.2, 68)	0.6
Male gender	10	0	0.6 (0.008, 3)	0.16

*Except where indicated otherwise, values reflect the number (%) of patients. Odd ratios (ORs) were determined for each variable based on a yes/no determination in patients with pSLE (n = 42). Potential risk factors identified by univariate analysis (P ≤ 0.1) were included in the multivariate models. Total number of SLE patients with adjusted mean SLE disease activity index (AMS) in the top quartile (AMS > 3.7) is 10; total number of SLE patients with change in SDI (ΔSDI) greater than 0 is 7. SDI, Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index; NGAL, neutrophil gelatinase-associated lipocalin.

ISSN: 1478-6362