Table 2 Shared toxicities of NSAIDs
Organ system | Toxicity |
|---|---|
Gastrointestinal | Dyspepsia |
| Â | Esophagitis |
| Â | Gastroduodenal ulcers |
| Â | Ulcer complications (bleeding, perforation obstruction) |
| Â | Small bowel erosions and strictures |
| Â | Colitis |
Renal | Sodium retention |
| Â | Weight gain and edema |
| Â | Hypertension |
| Â | Type IV renal tubular acidosis and hyperkalemia |
| Â | Acute renal failure |
| Â | Papillary necrosis |
| Â | Acute interstitial nephritis |
| Â | Accelerated chronic kidney disease |
Cardiovascular | Heart failure |
| Â | Myocardial infarction |
| Â | Stroke |
| Â | Cardiovascular death |
Hepatic | Elevated transaminases |
Asthma/allergic | Aspirin-exacerbated respiratory diseasea (susceptible patients) |
| Â | Rash |
Hematologic | Cytopenias |
Nervous | Dizziness, confusion, drowsiness |
| Â | Seizures |
| Â | Aseptic meningitis |
Bone | Delayed healing |