Figure 3

Distribution of individual Vκ genes in B cells from the peripheral blood and from the parotid gland of a patient with Sjögren's syndrome(SS) compared with those of peripheral blood B cells from normal healthy subjects (NHS). ^# The significant difference in the frequency of occurrence of VκB2 comparing the nonproductive and productive Vκ gene repertoire suggests negative selection of this gene segment (P < 0.005). Vκ gene usage of normal donors has been published elsewhere [10]. Vκ genes are arranged in order from J-proximal to J-distal.