Table 4 Older cartilage demonstrated reduced expression of many important cartilage genes compared with young cartilage.

DGE higher in old

ECM

Collagen, type X, alpha 1

COL10A1

-1.40

3.09 × 10^-2

Collagen, type XXV, alpha 1

COL25A1

-2.78

3.62 × 10^-4

Lubricin

CSPG4

-2.25

2.53 × 10^-5

Growth factor/cytokine

Fibroblast growth factor 9

FGF9

-3.33

4.16 × 10^-4

DGE lower in old

Protease

A disintegrin and metallopeptidase with thrombospondin 12

ADAMTS12

2.20

2.31 × 10^-2

A disintegrin and metallopeptidase with thrombospondin 2

ADAMTS2

5.41

1.43 × 10^-11

A disintegrin and metallopeptidase with thrombospondin 4

ADAMTS4

1.94

8.47 × 10^-4

Matrix metallopeptidase 1

MMP1

1.67

6.00 × 10^-3

Matrix metallopeptidase 13

MMP13

2.01

3.07 × 10^-4

Plasminogen activator inhibitor-1

SERPINE1

4.24

4.04 × 10^-16

Plasminogen activator, tissue

PLAT

1.86

4.19 × 10^-3

Matrix enzyme

Chondroitin sulfate synthase 3

CHSY3

1.54

2.10 × 10^-2

Hyaluronan synthase 3

HAS3

1.64

1.65 × 10^-2

Procollagen C-endopeptidase enhancer

PCOLCE

1.90

1.89 × 10^-3

ECM

Asporin

ASPN

1.55

2.72 × 10^-2

Biglycan

BGN

1.47

2.25 × 10^-2

Cartilage intermediate layer protein 2

CILP2

4.92

5.97 × 10^-19

Chondroadherin

CHAD

2.55

7.89 × 10^-6

Collagen alpha 1(V) chain

COL5A1

3.32

9.05 × 10^-11

Collagen, type I, alpha 1

COL1A1

6.55

1.49 × 10^-28

Collagen, type I, alpha 2

COL1A2

5.57

4.45 × 10^-25

Collagen, type II, alpha 1

COL2A1

6.53

1.29 × 10^-32

Collagen, type III, alpha 1

COL3A1

5.11

1.04 × 10^-22

Collagen, type IV, alpha 1

COL4A1

30.11

6.16 × 10^-3

Collagen, type IV, alpha 5

COL4A5

4.07

2.76 × 10^-6

Collagen, type IX, alpha 1

COL9A1

8.02

9.70 × 10^-32

Collagen, type IX, alpha 2

COL9A2

4.04

2.47 × 10^-15

Collagen, type VIII, alpha 1

COL8A1

3.66

3.79 × 10^-10

Collagen, type XI, alpha 1

COL11A1

2.01

2.79 × 10^-4

Collagen, type XII, alpha 1

COL12A1

1.68

5.11 × 10^-3

Collagen, type XIII, alpha 1

COL13A1

4.14

1.23 × 10^-4

Collagen, type XIV, alpha 1

COL14A1

3.66

9.07 × 10^-13

Collagen, type XV, alpha 1

COL15A1

2.21

7.11 × 10^-5

Collagen, type XVI, alpha 1

COL16A1

2.33

1.28 × 10^-5

Fibulin 1

FBLN1

4.83

4.44 × 10^-9

Fibulin-7

FBLN7

1.66

1.69 × 10^-2

Matrilin 2

MATN2

4.56

3.95 × 10^-17

Matrilin 4

MATN4

3.69

6.65 × 10^-8

Procollagen V, alpha 2

COL5A2

4.03

2.69 × 10^-15

Thrombospondin 2

THBS22

2.41

1.26 × 10^-4

Thrombospondin 3

THBS3

2.10

1.54 × 10^-4

Growth factor/cytokine

Fibroblast growth factor 12

FGF12

2.34

1.55 × 10^-2

Interleukin-11

IL11

1.48

2.46 × 10^-2

Interleukin-8

IL8

1.65

1.41 × 10^-2

Interleukin-1b

IL1B

6.26

8.91 × 10^-10

Tumour necrosis factor, alpha-induced protein 3

TNFAIP3

1.73

1.49 × 10^-2