From: Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism
Normal chondrocytes | Cells treated with 1 mM NOC-12 | Cells treated with 1 mM SNP | |
---|---|---|---|
Age, years | 49.8 ± 21.2 (14) | 44.2 ± 19.4 (5) | 59.7 ± 18.9 (11) |
Proteins, mg/ml | 3.1 ± 0.9 (14) | 2.8 ± 1.4 (5) | 4.2 ± 1.4 (11) |
CS enzymatic activity (nmol/min/mg protein) | 108.9 ± 38.5 (14) | 146.9 ± 54.7 (5) | 106.6 ± 26.2 (11) |
Mitochondrial complex activitya | |||
Complex I | 30.1 ± 13.4 (14) | 6.8 ± 2.3 (5)* | 22.8 ± 19.1 (11) |
Complex II | 7.4 ± 2.3 (14) | 6.8 ± 1.6 (5) | 10.2 ± 1.81 (11) |
Complex III | 53.5 ± 18.4 (14) | 35.2 ± 9.3 (5)* | 46.3 ± 9.7 (11) |
Complex IV | 61.2 ± 8.3 (14) | 15.7 ± 3.1 (5)* | 40.2 ± 11.3 (11)* |