BASELINE | Week 12 | Week 24 | Week 48 | Week 72 | Week 96 | Week 120 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DMARDs | RTX | DMARDs | RTX | DMARDs | RTX | DMARDs | RTX | DMARDs | RTX | DMARDs | RTX | DMARDs | RTX | |
Global disease activity VAS (mm) | 88.7 ± 3.3 | 88.7 ± 3.3 | 77 ± 2.2† | 72.4 ± 4.0‡ | 71 ± 3.2‡ | 68.5 ± 4.6‡ | 63 ± 3.9* | 60.0 ± 4.6* | 54 ± 3.5* | 51.8 ± 3.0* | 50.5 ± 3.7* | 47.1 ± 3.5* | 52.1 ± 4.8* | 45.3 ± 3.9* |
Pain VAS (mm) | 70.1 ± 9.0 | 71.1 ± 8.7 | 59.8 ± 7.8† | 55 ± 7.4† | 56.7 ± 7.8‡ | 53.5 ± 7.5‡ | 51.3 ± 7.5* | 44.1 ± 8.5* | 41 ± 7.6* | 36.3 ± 7.9* | 40.5 ± 7.5* | 33.1 ± 7.0* | 39.3 ± 8.3* | 29.8 ± 7.8* |
Fatigue VAS (mm) | 85.1 ± 4.6 | 83.8 ± 4.1 | 73 ± 4.5† | 63.1 ± 4.3‡ | 63.1 ± 4.7‡ | 58.7 ± 5.1‡ | 60.1 ± 4.4* | 56.2 ± 5.5* | 52.2 ± 4.0* | 47.8 ± 4.7* | 50.5 ± 3.8* | 42.5 ± 4.1* | 51.8 ± 4.5* | 41.1 ± 4.2* |
Dryness VAS (mm) | 71.0 ± 8.3 | 72 ± 8.5 | 61.1 ± 8.3 | 55.3 ± 7.6‡ | 58 ± 8.2† | 52.2 ± 7.6‡ | 56.3 ± 8.4‡ | 44.1 ± 8.5* | 53.8 ± 11.0* | 36.3 ± 7.9* | 51.8 ± 10.4* | 30.7 ± 8.0* | 51.8 ± 11.1* | 25.1 ± 7.7* |
Physician GA VAS (mm) | 89.7 ± 3.0 | 87.1 ± 2.3 | 78.6 ± 2.6† | 69.1 ± 3.0† | 73.1 ± 3.4‡ | 65 ± 4.4‡ | 65.0 ± 3.9* | 56.6 ± 4.3* | 56.6 ± 3.8* | 50.3 ± 3.0* | 54.7 ± 4.5* | 45.8 ± 3.3* | 56.1 ± 4.9* | 44.0 ± 3.7* |
Unstimulated salivary flow (ml/minute) | 0.08 ± 0.03 | 0.08 ± 0.04 | 0.1 ± 0.04 | 0.2 ± 0.04‡ | 0.1 ± 0.04 | 0.3 ± 0.04‡ | 0.1 ± 0.07 | 0.4 ± 0.02* | 0.1 ± 0.06 | 0.3 ± 0.001* | 0.1 ± 0.08 | 0.4 ± 0.04* | 0.1 ± 0.08 | 0.4 ± 0.04* |
Schirmer I test (mm/5 minutes) | 3.8 ± 0.6 | 3.8 ± 0.6 | 4 ± 0.5 | 5.5 ± 0.4‡ | 4.5 ± 0.7 | 6.0 ± 0.5† | 5.1 ± 0.8 | 6.3 ± 0.6‡ | 5.1 ± 0.7 | 7.0 ± 0.7* | 5.3 ± 0.7† | 7.0 ± 0.7* | 5.5 ± 0.8‡ | 7.3 ± 0.8* |
ESSDAI | 19.8 ± 3.1 | 20.3 ± 2.9 | 17.6 ± 3.2 | 14.2a ± 2.8 | 14.2 ± 3.0‡ | 9.8 ± 2.0‡ | 12.3 ± 2.0* | 9.4 ± 1.6‡ | 10.2 ± 2.0* | 5.7 ± 1.0* | 9.7 ± 2.0* | 5.7 ± 1.0* | 8.8 ± 1.7* | 5.2 ± 0.9* |