Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study

Table 3 Laboratory results in inflammatory bowel syndrome and fibromyalgia syndrome subgroups ^a

Laboratory test	IBS	IBS/FMS cases classified by Marsh stage			P value
	(N = 125)	(N = 104)			(Marsh stages 1 and 3 vs. Marsh stage 0)
		Normal mucosa	Lymphocytic enteritis	Villous atrophy
		Marsh stage 0 (n = 39)	Marsh stage 1 (n = 58)	Marsh stage 3 (n = 7)
IEL count per 100 epithelial cells	15 (10)	14 (2)	35 (5)	37 (5)	<0.001
Helicobacter pylori (+)	58 (46)	17 (43)	24 (41)	3 (43)	0.159
HLA-DQ2 A1/B1 (+)	30 (24)	15 (38)	31 (53)	6 (86)	0.052
IgA anti tTG-2, U/ml	0.4 (0.1)	0.5 (0.1)	0.9 (0.7)	60.4 (52)	0.001

^aHLA, major histocompatibility complex class II human leucocyte antigen; IBS, irritable bowel syndrome; IBS/FMS, irritable bowel syndrome plus fibromyalgia syndrome; IEL, intraepithelial lymphocyte count per 100 epithelial cells in duodenal biopsy sample; IgA, immunoglobulin A; tTG, tissue transglutaminase. Data are expressed as mean and standard deviation or total and percentage of the total value.

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