Table 1 Characteristics of patients with early rheumatoid arthritis (RA) and undifferentiated arthritis (UA) from the ESPOIR cohort
UA (n = 159) | Early RA (n = 632) | P value | |
|---|---|---|---|
Age | 47.2 ± 13.8 | 48.5 ± 12.2 | 0.46 |
Women ( n ,%) | 117 (74%) | 492 (78%) | 0.25 |
First symptom (months) | 6.6 ± 7.7 | 6.9 ± 8.5 | 0.72 |
DAS28 | 4.0 ± 1.0 | 5.4 ± 1.2 | <0.0001 |
CRP level (mg/L) | 17.2 ± 29.3 | 21.1 ± 33.1 | 0.0028 |
ESR | 25.3 ± 22.4 | 30.6 ± 24.9 | 0.0014 |
Positive anti-CCP antibodies ( n ,%) | 2 (1.26%) | 313 (49.5%) | <0.0001 |
Positive RF ( n ,%) | 5 (3.1%) | 365 (57.75%) | <0.0001 |
Swollen-joint count | 3.5 ± 2.4 | 8.2 ± 5.2 | <0.0001 |
Tender-joint count | 3.2 ± 2.6 | 9.9 ± 7.2 | <0.0001 |
HAQ score | 0.69 ± 0.58 | 1.05 ± 0.69 | <0.0001 |
Diabetes mellitus ( n ,%) | 7 (4.4%) | 24 (3.8%) | 0.73 |
HOMA-IR index | 2.5 ± 2.6 | 2.8 ± 4.2 | 0.37 |
BMI | 24.7 ± 4.6 | 25.2 ± 4.6 | 0.22 |
Steroid prescription at inclusion ( n ,%) | 22 (13.8%) | 84 (13.3%) | 0.86 |
Radiographic damage at inclusion ( n ,%) | 0 (0) | 108 (17.1%) | <0.0001 |
Total SHS at inclusion | 4.6 ± 6.8 | 6.14 ± 7.92 | 0.005 |
Erosive SHS | 1.6 ± 3.13 | 3.09 ± 4.98 | <0.0001 |
Narrowing SHS | 2.97 ± 4.82 | 3.04 ± 4.36 | 0.77 |
Total SHS at 1 year | 5.7 ± 9.5 | 7.7 ± 10.7 | 0.006 |
Erosive SHS | 2.35 ± 5.05 | 4.48 ± 7.56 | <0.0001 |
Narrowing SHS | 3.36 ± 5.54 | 3.26 ± 4.78 | 0.9552 |
Total ∆ SHS between inclusion and 1 year | 1.0 ± 3.8 | 1.6 ± 4.4 | 0.02 |
Erosive ∆ SHS between inclusion and 1 year | 0.73 ± 2.7 | 1.37 ± 3.73 | 0.0025 |
Narrowing ∆ SHS between inclusion and 1 year | 0.24 ± 1.22 | 0.26 ± 1.15 | 0.7294 |
Adiponectin level (μg/ml) | 4.9 ± 3.4 | 5.0 ± 3.7 | 0.63 |
Leptin level (ng/ml) | 14.6 ± 14.4 | 14.4 ± 13.7 | 0.74 |
Visfatin/NAMPT level (ng/ml) | 4.1 ± 3.6 | 3.57 ± 3.1 | 0.47 |