Figure 7

IL-16, CCL2, CCL7 and CXCL8 expression in non-degenerate, degenerate and infiltrated intervertebral discs (IVDs). Immunohistochemical quantification of IL-16, CCL2, CCL7 and CXCL8 expression by NP cells in non-degenerate (ND), degenerate (D) and infiltrated (I) IVDs. Data shown are median values for immunopositivity; black star, significant difference in expression between study groups (P <0.05). IL-16 expression was equivalent across study groups, CCL2, CCL7 and CXCL8 expression was increased in degenerate samples, CCL7 and CXCL8 expression was also increased in infiltrated samples.