From: Prevalence of methotrexate intolerance in rheumatoid arthritis and psoriatic arthritis
All patients | Tolerant to MTX | Intolerant to MTX | Oral MTX | Parenteral MTX | |
---|---|---|---|---|---|
Total | 291 (100) | 259 (89.0) | 32 (11.0) | 194 (66.7) | 97 (33.3) |
Cutoff score ≥6 | 32 (11.0) | 0 (0) | 32 (100) | 12 (6.2) | 20 (20.6)a |
Abdominal pain | 44 (15.1) | 24 (9.3) | 20 (62.5) | 7 (58.3) | 13 (65.0) |
After MTX | 33 (11.3) | 18 (6.9) | 15 (46.9) | 5 (41.7) | 10 (50.0) |
Anticipatory | 17 (5.8) | 5 (1.9) | 12 (37.5) | 5 (41.7) | 7 (35.0) |
Associative | 17 (5.8) | 6 (2.3) | 11 (34.4) | 4 (33.3) | 7 (35.0) |
Nausea | 100 (34.4) | 68 (26.3) | 32 (100) | 12 (100) | 20 (100) |
After MTX | 93 (32.0) | 61 (23.6) | 32 (100) | 12 (100) | 20 (100) |
Anticipatory | 25 (8.6) | 7 (2.7) | 18 (56.3) | 6 (50.0) | 12 (60.0) |
Associative | 32 (11.0) | 15 (5.8) | 17 (53.1) | 5 (41.7) | 12 (60.0) |
Vomiting | 22 (7.6) | 11 (4.2) | 11 (34.4) | 5 (41.7) | 6 (30.0) |
After MTX | 19 (6.5) | 9 (3.5) | 10 (31.3) | 5 (41.7) | 5 (25.0) |
Anticipatory | 5 (1.7) | 0 (0) | 5 (15.6) | 2 (16.7) | 3 (15.0) |
Behavioural symptoms | 48 (16.5) | 22 (8.5) | 26 (81.3) | 7 (58.3) | 19 (95.0)b |
Restlessness | 38 (13.1) | 16 (6.2) | 22 (68.8) | 6 (50.0) | 16 (80) |
Irritability | 29 (10.0) | 7 (2.7) | 22 (68.8) | 5 (41.7) | 17 (85.0)c |
Refusal of MTX | 13 (4.5) | 1 (0.4) | 12 (37.5) | 2 (16.7) | 10 (50.0) |