Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects

Table 5 Genetic risk score analysis

	Mean ± standard deviation		ū₁-ū₂^a	t ^a	P ^a	OR^b	P ^b	Variance explained (%)^c
	Case	Control	(95% CI)^a	t ^a	P ^a	(95% CI)	P ^b	Variance explained (%)^c
East Polynesian (H)	10.93 ± 1.56	10.45 ± 1.91	0.48	2.71	0.007	1.22	0.002	1.38
East Polynesian (H)	10.93 ± 1.56	10.45 ± 1.91	(0.13, 0.83)	2.71	0.007	(1.07-1.39)	0.002	1.38
East Polynesian (L)	4.81 ± 1.70	4.68 ± 1.96	0.13	0.47	0.64	1.03	0.77	0.09
East Polynesian (L)	4.81 ± 1.70	4.68 ± 1.96	(-0.44, 0.71)	0.47	0.64	(0.84-1.26)	0.77	0.09
West Polynesian	17.24 ± 1.21	16.57 ± 2.95	0.67	2.43	0.016	1.14	0.041	1.89
West Polynesian	17.24 ± 1.21	16.57 ± 2.95	(0.13, 1.22)	2.43	0.016	(1.01-1.30)	0.041	1.89
Polynesian	11.16 ± 1.54	10.23 ± 2.04	0.93	1.54	0.14	1.32	0.21	5.11
Polynesian	11.16 ± 1.54	10.23 ± 2.04	(-0.31, 2.18)	1.54	0.14	(0.85-2.05)	0.21	5.11
European Caucasian	3.02 ± 1.60	2.94 ± 1.52	0.08	0.75	0.45	1.01	0.80	0.04
European Caucasian	3.02 ± 1.60	2.94 ± 1.52	(-0.13, 0.28)	0.75	0.45	(0.93-1.11)	0.80	0.04

^aū₁-ū₂, difference in means (case (ū1) minus control (ū2)); t, t-value, P, two-tailed t-test P-value. ^bOR, odds ratio (adjusted by sex); P, logistic regression P-value. ^cBased on pseudo-R² calculated during logistic regression.

ISSN: 1478-6362