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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis

Figure 6

Articular cartilage degeneration six weeks after the injection of 500 U of collagenase. Extensive cartilage degeneration, comprising areas of marked erosion with exposure of the subchondral bone (white arrowhead; A, B), loss of proteoglycan staining and cell depletion (black arrow; B, C), chondrocyte clustering and hypertrophy (white arrow; B, C), fissures (black arrowhead; B, C) and tidemark undulation (*; C). Bar: 50 μm.

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Arthritis Research & Therapy

ISSN: 1478-6362

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