Figure 5From: Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937Normalized gene expression (Delta Ct) values for JUN and FOS in U937 cells were increased with MTX (1 uM) but not with HCQ (1 uM). The increases in JUN and FOS observed with added MTX were time- and dose-dependent (right two panels). Values represent mean and SEM; P values calculated using one-way ANOVA. ANOVA, analysis of variance; HCQ, hydroxychloroquine; MTX, methotrexate.Back to article page