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Table 1 Comparison of patients with SLE who never had serum NN with the rest of the group

From: Serum nitrated nucleosome levels in patients with systemic lupus erythematosus: a retrospective longitudinal cohort study

 

NN-negative

NN-positive

P-value

(n patients = 18)

(n patients = 31)

(n samples = 144)

(n samples = 253)

Mean age at first sample (SD)(*)

37.7 (13.1)

34.9 (12.8)

0.47

% Female (n)(*)

77.8 (14)

83.9 (26)

0.71

Ethnicity(*)

  

0.41

% AC (n)

27.8 (5)

41.9 (13)

 

% C (n)

61.1 (11)

38.7 (12)

% Other (n)

11.1 (2)

19.3 (6)

Median anti-dsDNA IU/ml (IQR)(**) (†)

29 (13, 97)

82 (17, 171)

0.18

Mean C3 g/l (SD)(**)

1.0 (0.2)

0.9 (0.3)

0.10

Median Global BILAG score (IQR)(**) (†)

5 (2, 8)

5 (3, 10)

0.22

% anti-Sm positive (n)(*)

0.0 (0)

35.5 (11)

0.004

% anti-RNP positive (n)(*)

27.8 (5)

32.3 (10)

1.00

% anti-Ro-positive (n)(*)

38.9 (7)

45.2 (14)

0.77

% anti-La positive (n)(*)

16.7 (3)

9.7 (3)

0.66

% on hydroxychloroquine (n)(**)

42.1 (61)

44.7 (113)

0.66

% on immunosuppressants (n)(**)

25.7 (37)

63.2 (160)

0.001

% on ≥5 mg/day corticosteroids (n)(**)

68.1 (98)

78.3 (198)

0.31

  1. (*)Analysis performed at the patient level.
  2. (**)Analysis performed at the sample level.
  3. (†)Statistical comparison performed on log scale.
  4. Footnote - Global BILAG score is calculated from the formula A = 9, B = 3, C = 1, D = 0, E = 0 as described in previous papers [12]. Bold type indicates statistically significant P-values (P <0.05). BILAG, British Isles Lupus Assessment Group; NN, nitrated nucleosomes; RNP, ribonucleoprotein; SLE, systemic lupus erythematosus.