From: Biology of platelet-rich plasma and its clinical application in cartilage repair
Cell type | Intervention | Outcome | Reference |
---|---|---|---|
Sheep BMSCs | Double-spun PRP activated by CaCl2 | Increased cell proliferation and Col II mRNA expression | [34] |
Human BMSCs | 50% platelet lysate after two cycles of freezing and thawing | Promoted proliferation and triggered chondrogenic differentiation | [55] |
Human BMSCs | 10% inactivated PRP (leukocyte concentration unreported) | Enhanced cell proliferation and Sox9, aggrecan and RUNX2 mRNA expression | [56] |
Rabbit BMSCs, ADSCs | 10% double-spun inactivated PRP | Increased cell proliferation and expression of Sox9, aggrecan, Col II and Col I mRNA and proteins | [21] |
Mouse MDSCs | Double-spun PRP | Promoted cell proliferation, adhesion and migration of MDSCs, and increased number of cells producing Col II and cell apoptosis | [58] |
Human subchondral progenitor cells | 5% P-PRP after freezing and thawing | Increased cell migration and cartilaginous matrix formation, but did not affect osteogenic and adipogenic differentiation | [60] |