Patients | All | PR | TR | P, PR vs. TR |
---|---|---|---|---|
Infusion #1 | ||||
Cmax (t = 2 h) mU/mL | 25.6 ± 5.0 | 26.2 ± 5.9 | 24.7 ± 3.4 | 0.45 (ns) |
C48h (t = 48 h) mU/mL | 22.4 ± 5.6 | 22.9 ± 6.3 | 21.7 ± 4.7 | 0.60 (ns) |
Cmin (t = 21 days) mU/mL | 4.9 ± 4.6 | 7.7 ± 3.8 | 1.0 ± 2.2 | <0.0001* |
T1/2, days | 11.4 ± 3.7a | 12.3 ± 3.7 | 9.7 ± 3.3a | 0.08 (ns) |
AUC2 h-21 days, mU*mL-1*d | 277 ± 112 | 328 ± 100 | 204 ± 85 | 0.0016* |
Infusion #5 | ||||
Cmax (t = 2 h) mU/mL | 31.4 ± 9 | 10.5 ± 12 | <0.0005* | |
C48h (t = 48 h) mU/mL | 29.9 ± 9.7 | 4.9 ± 7.3 | <0.0001* | |
Cmin (t = 21 days) mU/mL | 10.6 ± 5.1 | 0.2 | <0.0003* | |
T1/2, days | 13.8 ± 3.0 | -b | ||
AUC2 h-21 days, mU*mL-1*d | 422 | 44 | ||
AUC, inf #5/inf #1 | 1.3 | 0.2 | ||
Average for all infusions | ||||
Cmax (t = 2 h) mU/mL | 30.9 ± 2.9 | 16.9 ± 5.4 | 0.0009* | |
Cmin (t = 21 days) mU/mL | 9.9 ± 1.4 | 0.4 ± 0.4 | <0.0001* | |
T1/2, days | 13.0 ± 3.4 | -b | ||
AUC2 h-21 days, mU*mL-1*d | 397 ± 38 | 105 ± 65 | <0.0001* |