Bone mass and quality in patients with juvenile idiopathic arthritis: longitudinal evaluation of bone-mass determinants by using dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and quantitative ultrasonography

Stagi, Stefano; Cavalli, Loredana; Signorini, Carla; Bertini, Federico; Cerinic, Marco Matucci; Brandi, Maria Luisa; Falcini, Fernanda

doi:10.1186/ar4525

Table 2 Correlation coefficients (rho) between the bone traits in the JIA cohort and controls

From: Bone mass and quality in patients with juvenile idiopathic arthritis: longitudinal evaluation of bone-mass determinants by using dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and quantitative ultrasonography

pQCT phenotypes								DXA Phenotypes			QUS phenotypes
	TrbBMD	CrtBMD	Total density	CBA	Bone area	Muscle CSA	Fat CSA	SSIp	BMAD	BMD	QUS z-score	AD-SoS	BTT
TrbBMD		0.13	0.60***	0.10	0.14	0.26*	0.16	0.05	0.12	0.12	- 0.05	0.01	0.07
		0.19	0.59^^^	0.23^	0.19	0.31^^	0.29^	0.28^	0.35^^	0.15	0.09	0.14	0.18
		0.25°	0.78°°°	0.32°°	0.24°	0.35°°	−0.10	−0.26°	0.39°°	0.44°°	0.17	0.12	0.31°
CrtBMD			0.34**	0.23*	0.14	0.42***	0.09	0.36**	0.49**	0.69***	0.21*	0.60***	0.64***
			0.50^^^	0.52^^^	0.28^	0.39^^	0.16	0.41^^	0.46^^	0.72^^^	0.22^	0.70^^^	0.66^^^
			0.39°°	0.83°°°	0.49°°	0.70°°°	- 0.27°	0.39°°	0.63°°°	0.80°°°	0.61°°°	0.72°°°	0.82°°°
Tot density				0.11	0.19	0.41**	0.23	0.22*	0.12	0.46**	0.27*	0.43***	0.40***
				0.39^^	0.15	0.38^^	−0.20	0.23^	0.36^^	0.48^^	0.24^	0.50^^	0.42^^
				0.61°°°	0.29°	0.59°°°	0.10	0.32°°	0.24°	0.56°°°	0.18	0.35°°	0.43°°
CBA					0.11	0.22*	- 0.26*	0.25*	- 0.09	0.28**	0.12	0.24*	0.25*
					0.49^^	0.81^^^	−0.16	0.83^^^	0.25^	0.71^^^	0.31^^	0.48^^	0.72^^^
					0.82°°°	0.92°°°	0.14	0.42°°°	0.34°°	0.89°°°	0.57°°°	0.26°	0.85°°°
Bone area						0.49**	0.05	0.55**	0.20	0.18	0.05	0.18	0.30**
						0.49^^	0.11	0.66^^	0.31^^	0.40^^	0.09	0.19	0.37^^
						0.78°°°	0.37°°	0.72°°°	0.22°	0.75°°°	0.27°	0.47°°	0.71°°°
MuscleCSA							- 0.27*	0.47***	0.53***	0.66***	0.15	0.48**	0.76***
							−0.37^^	0.63^^^	0.42^^	0.61^^^	0.13	0.70^^^	0.80^^^
							0.02	0.38°°	0.34°°	0.86°°°	0.19	0.67°°°	0.85°°°
FatCSA								−040**	0.11	0.13	- 0.19*	- 0.11	- 0.14
								−0.48^^	−0.14	0.38^^	−0.05	−0.18	−0.16
								0.19	0.37°°	0.39°°	−0.22°°	−0.43°°	−0.31°°
SSIp									0.25*	0.52***	0.02	0.35**	0.56***
									0.21^	0.53^^^	0.11	0.31^^	0.51^^^
									0.24°	0.69°°°	0.16	0.53°°°	0.67°°°
BMAD										0.38***	- 0.01	0.16	0.02
										0.40^^	0.21^	0.28^	0.19
										0.29°	0.39°°	0.57°°°	0.68°°°
BMD											0.31**	0.78***	0.87***
											0.28^	0.76^^^	0.72^^^
											0.71°°	0.67°°°	0.86°°°
QUS z-score												0.56***	0.68***
												0.51^^^	0.59^^^
												0.54°°°	0.65°°°
AD-SoS													0.73***
													0.68^^^
													0.86°°°

The first line of each cell describes the correlation between bone parameters during transversal study of JIA patients; the second line of each cell describes the correlation between bone parameters during longitudinal study of JIA patients; the third line of each cell describes the correlation between bone parameters during transversal study of controls.
*JIA transversal study: *P < 0.05; **P < 0.005; ***P < 0.0005; JIA longitudinal study: ^P < 0.05; ^^P < 0.005; ^^^P < 0.0005; °Controls transversal study: °P < 0.05; °°P < 0.005; °°°P < 0.0005. AD-SoS, amplitude-dependent speed of sound; BTT, bone transmission time. CBA, cortical bone area; CrtBMD, cortical bone mineral density; FatCSA, fat cross-sectional area; JIA, juvenile idiopathic arthritis; a; MuscleCSA, muscle cross-sectional area; SSIp, density-weighted polar section modulus; QUS, quantitative ultrasonography; Tot density, total density. TrbBMD, trabecular bone mineral density.

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