Table 3 Phenotype characteristics of CD4 ⁺ CD25 ^+/high CD127 ^low/- T-cells from peripheral blood, synovial fluid and synovial membrane of rheumatoid arthritis and osteoarthritis patients ^a

CD45RA

22.9 ± 5

5 ± 3

2.8 ± 1

34.9 ± 13.6

6 ± 3

5.6 ± 2.5

0.0059^b

0.0006^c

0.0631

0.2377

21 (19.5 to 30.2)

4 (3 to 7)

2.8 (2 to 3.5)

30.8 (16.8 to 57.4)

7 (2 to 9)

6 (2.1 to 8.8)

CD45RO

83 ± 14.7

93 ± 7

94.7 ± 5.2

81.4 ± 8.5

92 ± 8

91.9 ± 7.2

0.4

0.0232^b

0.9554

0.6488

81 (70 to 99)

92 (87 to 99)

94.9 (89.4 to 99)

82 (60 to 95)

91 (81 to 98)

94.3 (80.9 to 99.8)

CD69

3.1 ± 1.9

88 ± 2

84.8 ± 0.2

1.9 ± 0.8

82.3 ± 5.3

81.2 ± 4.8

< 0.0001^c

0.0029^d

0.1623

0.4746

2.1 (1.9 to 5.2)

85 (80 to 92)

84.6 (78 to 89)

1.8 (0.9 to 3.7)

84 (77.3 to 88)

82.6 (74.6 to 84.9)

CD62L

94.6 ± 1.8

5 ± 2

2 ± 1

94.7 ± 4.4

3 ± 1

3.1 ± 0.5

< 0.0001^c

0.0293^b

0.8881

0.2480

94.5 (93.3 to 95.8)

3 (3 to 9)

2 (1.1 to 3.2)

95.3 (80.5 to 99.7)

3.5 (2 to 5)

3.1 (2.8 to 3.5)

CD152

12.6 ± 14

29.2 ± 12

36.2 ± 3.3

13 ± 6.5

31.5 ± 11

32.5 ± 8.2

0.0477^b

0.0049^d

0.7552

0.8530

5.7 (3.2 to 28.8)

33 (33 to 40)

36 (33 to 39)

16.3 (1 to 19)

30 (24 to 41)

32.5 (25 to 39.6)

CD154

13.5 ± 6.3

11 ± 5.7

15.1 ± 8.8

8.8 ± 5.4

12 ± 8

13.4 ± 8.2

0.5892

0.2863

0.2361

0.8486

13.4 (7 to 19.5)

13 (6 to 18)

15.1 (7 to 23)

8.5 (1.4 to 19)

11 (5 to 20)

10 (7.5 to 18)

CD274

23.5 ± 2.8

25 ± 7

27.6 ± 5.7

9.8 ± 10.4

25 ± 7

24.1 ± 7.9

0.3758

0.0313^b

0.0329^b

0.5541

23 (21 to 26)

32 (20 to 29)

31 (21 to 31)

6 (0.5 to 40)

26 (17 to 34)

24.1 (17 to 30.9)

CD279

3.3 ± 3.3

23.2 ± 12

22.6 ± 11

5.4 ± 6.5

9 ± 9

7.9 ± 10

0.0231^b

0.6677

0.8127

0.0239^b

3 (0.2 to 6.7)

24 (14 to 32)

22.6 (15 to 30.1)

2.2 (0 to 23.1)

8 (2 to 15)

8 (0.8 to 15)

GITR

30.3 ± 22.7

42.5 ± 7.3

45.5 ± 6.8

40.5 ± 12.8

49.2 ± 12

47.4 ± 11.9

0.329

0.173

0.636

0.8114

31.4 (7 to 52.4)

43 (39 to 51)

45.1 (38.9 to 52)

43.8 (18.4 to 59.1)

13.9 (33 to 59)

11.94 (30 to 58.7)