Figure 2

Network analysis of juvenile idiopathic arthritis (JIA)-associated genes. (A) A collated list of 348 JIA-associated genes was used to derive an interaction network inferred from the BioGRID model of the human interactome (3.2.99); red = JIA-associated gene, blue = inferred interaction (Figure 1B). (B) Minimal essential network of top 10% of the genes from the JIA interactome, ranked by connectivity and bottleneck, colours represent clusters of related genes calculated by spectral partition clustering [41] (Figure 1Bi). (C) Biological pathways associated with minimal essential network (MEN) clusters (colour of cluster relates to Figure 2B), false discovery rate (FDR) P-value of hypergeometric test (P ≤0.05) (Figure 1Bi). MHC Major histocompatibility complex, FGF Fibroblast growth factor, PDGF Platelet-derived growth factor IGF-1 Insulin-like growth factor 1, TGF beta Transforming growth factor beta, IL-2 Interleukin 2, IL-8 Interleukin 8 PI3K Phosphoinositide 3-kinase, TNF Tumour necrosis factor, CXCR1 chemokine (C-X-C motif) receptor 1, CXCR2 chemokine (C-X-C motif) receptor 2.