From: The role of human T-lymphocyte-monocyte contact in inflammation and tissue destruction
Stimulus | Type of T cell | Type of monocyte | Products | References |
PHA/PMA | PB TL, HUT-78 cells, Jurkat cells, synovial and PB T cell clones: CD4+; CD8+; Th1; and Th2 | PB monocytes, THP-1 cells | TNF-α, IL-1β, IL-6, IL-8, IL-1α, IL-1Ra, TNFsRs, MMP-1 MMP-9, TIMP-1 | |
PdBu/ionomycine | PB TL | PB monocytes | TNF-α, IL-10 | [19] |
anti-CD3 | PB TL, synovial T cells | PB monocytes, THP-1 cells | TNF-α, IL-10, IL-1β; MMP-1 | |
anti-CD3 and anti-CD28 or specific Ag | Th1 cell clones | THP-1 cells | IL-1β, low IL-1Ra | [7] |
anti-CD3 and anti-CD28 or specific Ag | Th2 cell clones | THP-1 cells | IL-1Ra, low IL-1β | [7] |
Cytokines* | PB TL, synovial T cells, Th1 and Th2 cell clones | PB monocytes | TNF-α, IL-1β | |
Anti-CD3 | PB TL | PMA/IFN-γ-treated U937 cell | TNF-α, IL-10, IL-12 and IL-4 | [64] |