Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats

Table 1 Total number of cells in lymph nodes in DA and E3 naïve rats and rats 8 days after pristane injection

	Total cell number (millions)
Cell type	DA day 0*	E3 day 0*	Difference between DA and E3 on day 0**	DA day 8	E3 day 8	Difference between DA and E3 on day 8**
Leucocytes	10 ± 1.5	8 ± 0.79	NC, P < 0.1	27 ± 3.6	45 ± 21	NC, P < 0.3
Granulocytes	0.034 ± 0.01	0.052 ± 0.01	D, P < 0.04	0.48 ± 0.14	0.92 ± 0.62	NC, P < 0.5
B cells	1.8 ± 0.64	2.3 ± 0.29	NC, P < 0.25	6.3 ± 1.2	24 ± 13	D, P < 0.03
αβ T cells	7.9 ± 0.7	5.4 ± 0.3	I, P < 0.02	20 ± 1.3	19 ± 2.8	NC, P < 1
CD4⁺/αβ T cells	6.2 ± 0.5	4.3 ± 0.2	MI, P < 0.08	14 ± 0.9	13 ± 1.7	NC, P < 0.3
CD8⁺/αβ T cells	2.2 ± 0.2	1.7 ± 0.1	NC, P < 0.2	6.1 ± 0.7	7.5 ± 1.4	NC, P < 0.3
γδ T cells	0.024 ± 0.013	0.038 ± 0.0086	MD, P < 0.1	0.048 ± 0.018	0.24 ± 0.16	D, P < 0.03
NK cells	0.095 ± 0.034	0.12 ± 0.01	NC, P < 0.4	0.46 ± 0.07	1.51 ± 1.0	NC, P < 0.2
NK T cells	0.054 ± 0.019	0.12 ± 0.024	D, P < 0.02	0.19 ± 0.035	2 ± 1.2	D, P < 0.03

*Mean total cell number (in millions) ± standard deviation (SD) determined by fluorescence activated cell sorting (FACS) analysis. Data based on three DA and E3 naïve rats and three DA and E3 rats 8 days after pristane injection. **Difference in cell number: DA versus E3. P values calculated by Mann–Whitney nonparametric test. D, decrease; I, increase; MD, marginally decrease; MI, marginally increase; NC, no change.

ISSN: 1478-6362