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Table 3 Genes differentially expressed in naïve (day 0) DA versus E3 rats

From: Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats

Accession no.

Gene ID

Significance

Affymetrix

Custom-made

FACS

ELISA

Upregulated

      

   X56596

MHC class II antigen RT1.B-1 β-chain (MhcII)

T

I (56.8)

NC

I (1.2); P < 0.08

ND

   X00923

IgE heavy chain (Ig ε)

S

I (3.6)

I (1.9); P < 0.1

ND

I (1.4); P < 0.05

   D49955

Bone marrow stromal cell antigen 1 (Bst1)

T

I (3.7)

I (2.0); P < 0.1

ND

ND

Downregulated

      

   S81289

IgM κ chain variable region (CDR1 to CDR3 region; Ig κ)

S

D (-3.6)

D (-1.6); P < 0.0005

NC

ND

  1. To be regarded as differentially expressed a gene must be differentially expressed in two biological samples analyzed by a minimum of two independent methods. Differential expression values in bold text are statistically significant by that particular method. Genes significantly differentially expressed by a minimum of two independent methods are denoted 'S'. Another subset of genes showed a strong tendency toward differential expression; these are denoted 'T'. ELISA, enzyme linked immunosorbent assay; FACS, fluorescence activated cell sorting; NC, no change (for these genes, no statistically significant differential expression could be shown); ND, not determined.
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Arthritis Research & Therapy

ISSN: 1478-6362

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