Figure 7

Epigallocatechin 3-gallate reduces osteoarthritis-related pain symptoms. Behavior assessments of mice that underwent sham operations or surgical destabilization of the medial meniscus (DMM) that were treated with vehicle or epigallocatechin 3-gallate (EGCG) at 8 weeks after DMM surgery. (A) Distance traveled. (B) Number of times mice reared in an open cage within 6 minutes. (C) von Frey testing (mechanical allodynia). (D) Gene expression of monocyte chemoattractant protein 1 (Mcp1), chemokine receptor 2 (Ccr2), interleukin 1 beta (Il1b) and tumor necrosis factor alpha (Tnfa) in the ipsilateral L3-L5 dorsal root ganglion (*P < 0.05 by analysis of variance; n = 6/group). N.S., Not significant.