Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study

Muthuri, Stella G; Zhang, Weiya; Maciewicz, Rose A; Muir, Kenneth; Doherty, Michael

doi:10.1186/s13075-015-0534-4

Arthritis Research & Therapy

Table 4 Odds ratios for hip OA according to alcoholic and non-alcoholic beverage consumption

From: Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study

Beverage	Frequency of consumption	Hip OA	Controls	CRUDE ORs				Adjusted ^a OR				Adjusted ^b OR
Beverage	Frequency of consumption	Number	Number	ORs	95.0% CI		P value	ORs	95.0% CI		P value	ORs	95.0% CI		P value
Alcoholic ^c
Total alcohol intake	Nondrinkers^d	257	186	1.00				1.00				1.00
	< = 2 per week	90	93	0.70	0.50	0.99	0.044	0.66	0.46	0.96	0.031	0.63	0.42	0.94	0.025
	3 to 6 per week	174	168	0.75	0.56	1.00	0.047	0.88	0.65	1.20	0.432	0.88	0.63	1.24	0.468
	7 to 14 per week	164	204	0.58	0.44	0.77	<0.001	0.83	0.60	1.13	0.232	0.75	0.53	1.06	0.106
	> = 15 per week	280	261	0.78	0.60	1.00	0.050	1.42	1.03	1.96	0.030	1.27	0.90	1.81	0.177
	P trend						0.022				0.062				0.265
Beer (half pints)	None^e	384	340	1.00				1.00				1.00
	< = 3 per week	119	130	0.81	0.61	1.08	0.153	0.84	0.62	1.15	0.285	0.79	0.56	1.11	0.169
	4 to 7 per week	121	139	0.77	0.58	1.02	0.072	1.13	0.82	1.55	0.460	1.15	0.81	1.64	0.435
	8 to 19 per week	156	162	0.85	0.65	1.11	0.236	1.44	1.03	2.00	0.030	1.49	1.04	2.15	0.031
	> = 20 per week	185	141	1.16	0.89	1.51	0.264	2.36	1.65	3.37	<0.001	2.15	1.45	3.19	<0.001
	P trend						0.703				<0.001				<0.001
Wine (glasses)	None^e	703	579	1.00				1.00				1.00
	< = 1 per week	37	43	0.71	0.45	1.11	0.136	0.68	0.42	1.09	0.111	0.67	0.39	1.14	0.140
	2 to 3 per week	102	110	0.76	0.57	1.02	0.069	0.83	0.60	1.14	0.242	0.97	0.68	1.38	0.868
	4 to 6 per week	61	103	0.49	0.35	0.68	<0.001	0.63	0.44	0.91	0.013	0.68	0.45	1.03	0.070
	> = 7 per week	62	77	0.66	0.47	0.94	0.022	0.91	0.62	1.33	0.624	0.88	0.58	1.34	0.549
	P trend						<0.001				0.052				0.181
Spirits (tots)	None^e	756	654	1.00				1.00				1.00
	< = 1 per week	43	43	0.87	0.56	1.34	0.514	0.86	0.54	1.38	0.534	1.01	0.60	1.71	0.972
	2 to 3 per week	73	76	0.83	0.59	1.16	0.283	0.91	0.63	1.31	0.612	0.90	0.60	1.35	0.610
	4 to per week	53	64	0.72	0.49	1.05	0.084	0.84	0.56	1.25	0.391	0.63	0.41	0.98	0.040
	> = 8 per week	40	75	0.46	0.31	0.69	<0.001	0.59	0.39	0.91	0.017	0.53	0.33	0.85	0.008
	P trend						<0.001				0.020				0.002
Non-alcoholic ^f,c
Tea (cups)	= <1 per day	150	190	1.00				1.00				1.00
	2 to 3 per day	310	271	1.45	1.11	1.90	0.007	1.19	0.89	1.60	0.240	1.08	0.77	1.51	0.656
	4 to 5 per day	315	290	1.38	1.05	1.80	0.019	1.14	0.85	1.52	0.386	1.05	0.74	1.47	0.797
	6+ per day	204	170	1.52	1.13	2.04	0.005	1.36	0.99	1.88	0.058	1.18	0.81	1.71	0.389
	P trend						0.019				0.112				0.472
Coffee (cups)	= <6 per week	387	354	1.00				1.00				1.00
	1 per day	269	195	1.26	1.00	1.59	0.051	1.12	0.88	1.44	0.358	1.11	0.85	1.47	0.438
	2 to 3 per day	243	249	0.89	0.71	1.12	0.329	0.95	0.74	1.21	0.675	0.97	0.74	1.28	0.850
	= >4 per day	80	123	0.59	0.43	0.82	0.001	0.79	0.56	1.12	0.183	0.86	0.58	1.30	0.483
	P trend						0.004				0.241				0.582
Pure fruit juice (glasses)	<1/month	429	368	1.00				1.00				1.00
	1/month to 1 / week	265	251	0.91	0.73	1.13	0.381	1.06	0.84	1.35	0.607	1.01	0.78	1.31	0.918
	2 to 6 per week	170	176	0.83	0.64	1.07	0.145	1.05	0.80	1.38	0.743	1.14	0.84	1.54	0.413
	> = 1 per day	115	126	0.78	0.59	1.04	0.097	0.81	0.59	1.11	0.194	0.88	0.62	1.25	0.482
	P trend						0.050				0.397				0.880

^aadjusted for age, gender, BMI, smoking; ^badjusted for age, gender, BMI, smoking, other alcoholic/non-alcoholic beverages^c, occupational risks, significant injury, kidney disease, energetic physical activity at ages 21 to 50 and gout. ^dincludes participants who did not drink alcohol on a regular basis (at least one alcoholic drink per week) during age period 21 to 50 years. ^eincludes alcohol abstainers at ages 21 to 50 and drinkers of other alcoholic drinks. ^fAnalyses are based on age period 30 to 40 years when information on non-alcoholic beverage consumption was assessed. BMI, body mass index; CI, confidence interval; OA, osteoarthritis; OR, odds ratio.

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