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Table 1 Association of IL6R locus SNPs with the severity of joint damage in RA

From: Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

    

Discovery phase

Replication phase

 

SNP

Base pair

Minor allele

MAF

βa (95 % CI)

P value

βa (95 % CI)

P value

Meta-analysis P valueb

rs4845618

154,400,015

G

0.44

−1.09 (−1.85 to −0.33)

0.0052

−1.01 (−1.74 to −0.28)

0.007

0.00011

rs4453032

154,414,086

G

0.40

0.25 (−0.51 to 1.01)

0.51

–

–

–

rs4845374

154,426,947

A

0.17

1.14 (0.18–2.10)

0.02

0.95 (0.04–1.85)

0.04

0.0021

rs6698040

154,432,948

T

0.21

−0.79 (−1.75 to 0.17)

0.11

–

–

–

rs4379670

154,439,865

T

0.16

−0.64 (−1.72 to 0.44)

0.25

–

–

–

  1. CI confidence interval, IL6R interleukin-6 receptor gene, MAF minor allele frequency, RA rheumatoid arthritis, SNP single nucleotide polymorphism
  2. aCorrelation coefficient estimate, indicating the fold difference in joint damage in the presence of the minor allele (i.e., negative coefficients indicate a decrease in joint damage, positive coefficients indicate an increase of joint damage)
  3. b P value estimated from the meta-analysis of the significance and effect sizes of discovery and replication cohorts
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Arthritis Research & Therapy

ISSN: 1478-6362

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