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Table 1 Affinity and potency of CDP7657 and hu5c8

From: CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study

Assay

CDP7657

Hu5c8

BIAcore affinity (KD)

7.9 pM

33 pM

CD40 binding (IC50)

44 ng/mL (490 pM)

44 ng/mL (293 pM)

CD40L-dependent B-cell activation (ICAM-1 expression) (IC50)

83 ng/mL (920 pM)

38 ng/mL (253 pM)*

  1. *Activity in this assay is very sensitive to the valency of anti-CD40L antibodies tested, and the IC50 for hu5c8 Fab is 977 ng/mL (n = 20). CD40L CD40 ligand, ICAM intercellular adhesion molecule 1
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Arthritis Research & Therapy

ISSN: 1478-6362

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