CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study

Table 4 Thromboembolic potential of CDP7657 in an extended 3-month study in Rhesus monkeys

Dose group	Total animals affected (%)	Total affected lung sections	Total examined lung sections^a	Lung sections affected (%)
Control^b	10 (50)	11	581	1.9
(n = 10/sex)	10 (50)	11	581	1.9
20 mg/kg	6 (60)	9	290	3.1
(n = 5/sex)	6 (60)	9	290	3.1
50 mg/kg	4 (40)	4	294	1.4
(n = 5/sex)	4 (40)	4	294	1.4
200 mg/kg	3 (33)	3	261	1.2
(n = 5/sex)	3 (33)	3	261	1.2

Thromboembolic events defined as the occurrence of a thrombus or an organizing thrombus (intimal hyperplasia was not observed in this study); ^atotal number of lung sections examined in each group = 29/animal; ^btreated with i.v. saline

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