A longitudinal genome-wide association study of anti-tumor necrosis factor response among Japanese patients with rheumatoid arthritis

Table 3 Index SNPs from independent chromosomal regions showing borderline significant association with repeated measures of response at 3 and 6 months

SNP	Chr	Position (bp)	Minor allele	MAF	Genotype	N	β (95 % CI)	P value	Gene(s) in region of association
rs284515	6	91,208,828	G	0.17	AG/GG	134	0.35 (0.21, 0.49)	6.6×10⁻⁷	MAP3K7, BACH2
					AG	121	0.33 (0.16, 0.51)	2.1×10⁻⁴
					GG	13	0.80 (0.43, 1.18)	2.6×10⁻⁵
rs75908454	6	169,970,623	C	0.10	CT/CC	88	0.42 (0.26, 0.59)	6.3×10⁻⁷	WDR27
					CT	87	0.41 (0.24, 0.59)	2.3×10⁻⁶
					CC	1	-	-
rs1679568	10	117,817,551	A	0.15	AG/AA	124	0.35 (0.21, 0.49)	8.1×10⁻⁷	GFRA1
					AG	114	0.37 (0.20, 0.54)	1.6×10⁻⁵
					AA	10	0.63 (0.24, 1.02)	1.6×10⁻³

The single nucleotide polymorphisms (SNP) with the smallest p value (index SNP) in each of the associated regions are shown. β (regression coefficient) represents the increase in change in DAS28 associated with the genotype(s) shown compared to the reference genotype (with no minor alleles). Chr chromosome, MAF minor allele frequency, N number of patients with genotype(s) shown

ISSN: 1478-6362