Fig. 7From: Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosusQuantification of 27 cytokines and chemokines in sera of SLE patients and controls using bead-based multiplex assays. a Seventeen cytokines showed significant difference in SLE patients compared with NC, 15 were increased and two were decreased in both SLE LN− and SLE LN+ compared with NC (* p < 0.05). b mRNA expression level in PBMC for the cytokines which showed significant difference in sera of SLE patients. IL-15 mRNA was significantly upregulated and CCL5 mRNA were downregulated in PBMC of SLE patients compared with NC (* p < 0.05). c Six CpG sites in the IL-15 gene were hypomethylated and three CpG sites in CCL5 (RANTES) gene were hypomethylated in PBMC of SLE compared with NC. (* p < 0.05). NC normal controls, SLE systemic lupus erythematosus, SLE LN + SLE with lupus nephritis, SLE LN − SLE without lupus nephritisBack to article page