Fig. 2
Adenosine 2A receptors (A2AARs) are upregulated in lymphocytes from patients with systemic lupus erythematosus (SLE). a Saturation curves and b Scatchard plot showing the binding of 3H-ZM 241385 to A2AARs in lymphocyte membranes derived from 80 healthy control subjects (solid circles) and 80 patients with SLE (solid squares) are also shown. Saturation binding experiments were performed as described in the Methods section. Data in the saturation curves are expressed as the mean ± SEM of results pooled from one experiment performed in duplicate for the indicated number of subjects. c Linear regression analysis between Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2 K) score and maximum number of A2AARs (Bmax) in lymphocytes (n = 80, r = 0.68, p < 0.0001 by using Pearson’s or Spearman’s correlation (Pearson’s r = −0.68, Spearman’s r = −0.75)