Fig. 1

Increased lymphatic flow from flaring joints normalizes with effective anti-TNF therapy. Images of ⁹⁹Tc sulfur colloid tracing of the lower extremity to the pelvis obtained from a RA patient with asymmetric knee flare enrolled in a clinical study to assess the effects of anti-TNF therapy on arthritis and lymphatics (ClinicalTrials.gov NCT01083563). Note the bright ⁹⁹Tc sulfur colloid signal in the inguinal (arrows) and popliteal (arrowheads) areas on both lower extremities pre treatment, and the decreased signal post treatment, which resulted in normalization of the tt from 15 minutes to 60 minutes. Schematic diagram between the lymposcintigrams orients the regions of interest. R right leg, L left leg